Manhattan measures 22.7 square miles and is home to about two million culturally diverse residents.
Here is a guide to the major neighbourhoods of Manhattan.
Financial District The sourthernmost tip of Manhattan and the economic hub of the nation. See the skyscrapers of Wall St, the New York Stock Exchange or enjoy shopping and dining at the South Street Seaport.
Tribeca Cobblestoned streets that were once lined with 19th century warehouses in the TRIangle BElow CAnal St, are now home to trendy shops, cafes, gallaries and bars.
Chinatown Along these narrow streets and boulevards are markets, eateries and shops selling everything from jade to bird's nests.
Soho The hip area located SOuth of HOuston St has cast iron buildings, cafes, bistros, trendy bars and cutting edge fashion boutiques.
Little Italy The colourful streets, such as Mulberry, are where in-the-know Italian food lovers go for home style pasta and cannolis.
Lower East Side Visitors can head to this diverse melting pot for kosher pickles, knishes, designer bargains, historic sites and drinks and dinner at hip haunts.
Greenwich Village The ultra hip East Village is best known for its tattoo parlors, the Public Theatre, bars and eateries. The West Village, famous for attracting the creative and rebellious, is home to performers and chess players in Washington Square Park, as well as clubs, coffeehouses, shops, bars and restaurants.
Meatpacking District Once full of industry, this area is now the cutting edge of cool, with trendy eateries, bars, boutiques, galleries, dance spots, furniture and antique stores.
Chelsea A thriving contemporary art scene has given new life to this waterfront area.
Flatiron District Home to the famous 22 story building at 23rd St & Fifth Ave, dubbed the Flatiron, due to its triangular shape. Highlights include the Union Square Greenmarket, acclaimed eateries and nightspots.
Gramercy Park This histroic and fashionable area of tree lined streets contains a wealth of shopping and dining establishments.
Murray Hill With the Morgan Library & Museum and the Empire State Building as two landmarks, this neighbourhood also boasts excellent dining options.
Midtown Attractions include Grand Central Terminal, Rockefeller Center, Carnegie Hall, Radio City Music Hall, the Museum of Modern Art, stores and restaurants.
Theater District The city that never sleeps is at its most hyperactive in Times Square. Side streets are lined with restaurants, stores and the famous theaters in which Broadway plays and musicals are staged.
Central Park This 843 acre oasis provides sanctuary for birds and is a playground for humans of all ages with its carousel, zoo, ice skating and boating lake.
Upper East Side Along affluent Fifth Ave, the Metropolitan Museum of Art, Guggenheim Museum and Frick Collection are three links in the Museum Mile chain, while Madison Ave is home to exclusive boutiques and galleries.
Upper West Side Major attractions in this culturally rich and ethnically diverse area include Lincoln Center, the American Museum of Natural History, plus boutiques, gourmet shops, fine restaurants and hip bars.
Harlem Known for jazz music, gorgeous architecture and renowned churches, the neighbourhood now enjoying its second renaissance also features restaurants, stores and clubs.